EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.6.5.5 | structure in the free state at 2.3 A resolution. VAT-1 forms a dimer with the conserved NADPH-binding cleft on each protomer. The structure of VAT-1 in the NADP-bound state at 2.6 A resolution shows that NADP binds the binding cleft to create a putative active site with the nicotine ring | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.6.5.5 | 0.0299 | - |
9,10-phenanthrenequinone | pH 7.8, 25°C | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.6.5.5 | mitochondrion | - |
Homo sapiens | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.5.5 | Homo sapiens | A0A024R1Z6 | - |
- |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.6.5.5 | 0.64 | - |
substrate 9,10-phenanthrenequinone, pH 7.8, 25°C | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.5.5 | 1,2-naphthoquinone + NADPH + H+ | - |
Homo sapiens | 1,2-naphthoquinol + NADP+ | - |
? | |
1.6.5.5 | 9,10-phenanthrenequinone + NADPH + H+ | - |
Homo sapiens | 9,10-phenanthrenequinol + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.6.5.5 | VAT-1 | - |
Homo sapiens |
1.6.5.5 | vesicle amine transport protein-1 | - |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.6.5.5 | 1.13 | - |
9,10-phenanthrenequinone | pH 7.8, 25°C | Homo sapiens |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.6.5.5 | 37.8 | - |
9,10-phenanthrenequinone | pH 7.8, 25°C | Homo sapiens |